Craig Bellamy has been ruled out Wales' World Cup qualifier with England on 3 September because of a thigh injury.
Bellamy has been named in the squad for the double-header with England and Poland, but manager John Toshack says the striker will not play in Cardiff.
Said Toshack: "He'll probably be devastated that he won't be involved."
Toshack has also named the eight other players who missed this week's friendly with Slovenia, but there is no room in the 25-man squad for Robbie Savage.
It is the first time Savage has been omitted from a Wales squad for a qualifying match since the 30-year-old declared his wish to end his self-imposed international retirement.
Ben Thatcher is included in the 25-man squad despite being suspended for the England game in Cardiff's Millennium Stadium on 3 September.
But his three-match suspension for stamping on a Polish player will have ended for him to be available for the trip to Warsaw four days later.
Bellamy missed Wednesday's 0-0 draw in Swansea after picking up a fresh injury in training a day before.
Toshack added: "It was a big blow to be without him against Slovenia.
"He'd come down (to the Wales camp) and trained for two days with a lot of enthusiasm - maybe over enthusiastic, very keen to put the ankle injury behind him and play the game."
Mark Delaney is also a major doubt for the England game with a knee injury which has kept him on the sidelines this season.
Toshack also admitted defenders James Collins and Danny Collins faced a race against time to recover from their injuries.
Ryan Giggs missed the Slovenia with a chest infection and has been left out of Manchester United's squad to play Aston Villa on Saturday despite training with the club this week.
With no wins from their six games in Group Five, Wales have no hope of reaching the finals in Germany next year.
But a win against either of their next opponents would have a major impact on who qualifies as group winners.

Wales squad to play England in Cardiff on 3 September and Poland in Warsaw on 7th September:

Coyne (Burnley), Jones (Wolves), Price (Ipswich), D Collins (Sunderland), J Collins (West Ham), Delaney (Aston Villa), Duffy (Portsmouth), Edwards (Wolves), Gabbidon (West Ham), Page (Coventry), Partridge (Bristol City), Ricketts (Swansea), Roberts (Tranmere), Thatcher (Man City), Davies (Everton), Fletcher (West Ham), Koumas (West Brom), Parry (Cardiff), Robinson (Sunderland), Vaughan (Crewe), Williams (West Ham), Bellamy (Blackburn), Earnshaw (West Brom), Giggs (Man Utd), Hartson (Celtic).

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